2021 San Francisco 49ers Schedule
| Pre Season |
|---|
| Opponent |
| KC |
| @ LAC |
| LV |
| Reg. Season |
| Opponent |
| @ DET |
| @ PHI |
| GB |
| SEA |
| @ ARI |
| BYE WEEK |
| IND |
| @ CHI |
| ARI |
| LAR |
| @ JAC |
| MIN |
| @ SEA |
| @ CIN |
| ATL |
| @ TEN |
| HOU |
| @ LAR |
| Post Season |
| Opponent |
| @ DAL |
| @ GB |
| @ LAR |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/14 | 19 - 16 L | 0-1-0 | - | - | ||
| 08/22 | 15 - 10 W | 1-1-0 | - | - | NFL Network | |
| 08/29 | 10 - 34 W | 2-1-0 | - | - | NFL Network | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/12 Wk 1 | 41 - 33 W | 3-1-0 | - | - | FOX | |
| 09/19 Wk 2 | 17 - 11 W | 4-1-0 | - | - | FOX | |
| 09/26 Wk 3 | 30 - 28 L | 4-2-0 | - | - | NBC | |
| 10/03 Wk 4 | 28 - 21 L | 4-3-0 | - | - | FOX | |
| 10/10 Wk 5 | 10 - 17 L | 4-4-0 | - | - | FOX | |
| - | - | - | - | - | - | - |
| 10/24 Wk 7 | 30 - 18 L | 4-5-0 | - | - | NBC | |
| 10/31 Wk 8 | 33 - 22 W | 5-5-0 | - | - | FOX | |
| 11/07 Wk 9 | 31 - 17 L | 5-6-0 | - | - | FOX | |
| 11/15 Wk 10 | 10 - 31 W | 6-6-0 | - | - | ESPN | |
| 11/21 Wk 11 | 30 - 10 W | 7-6-0 | - | - | FOX | |
| 11/28 Wk 12 | 26 - 34 W | 8-6-0 | - | - | FOX | |
| 12/05 Wk 13 | 23 - 30 L | 8-7-0 | - | - | CBS | |
| 12/12 Wk 14 | 26 - 23 W | 9-7-0 | - | - | CBS | |
| 12/19 Wk 15 | 13 - 31 W | 10-7-0 | - | - | CBS | |
| 12/23 Wk 16 | 17 - 20 L | 10-8-0 | - | - | NFL Network | |
| 01/02 Wk 17 | 7 - 23 W | 11-8-0 | - | - | CBS | |
| 01/09 Wk 18 | 27 - 24 W | 12-8-0 | - | - | FOX | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 01/16 Wk 19 (Pre) | 23 - 17 W | 13-8-0 | - | - | Amazon Prime Video | |
| 01/22 Wk 20 (Pre) | 13 - 10 W | 14-8-0 | - | - | FOX | |
| 01/30 Wk 21 (Pre) | 17 - 20 L | 14-9-0 | - | - | FOX | |