2021 Detroit Lions Schedule
| Pre Season |
|---|
| Opponent |
| BUF |
| @ PIT |
| IND |
| Reg. Season |
| Opponent |
| SF |
| @ GB |
| BAL |
| @ CHI |
| @ MIN |
| CIN |
| @ LAR |
| PHI |
| BYE WEEK |
| @ PIT |
| @ CLE |
| CHI |
| MIN |
| @ DEN |
| ARI |
| @ ATL |
| @ SEA |
| GB |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/13 | 16 - 15 L | 0-1-0 | - | - | NFL Network | |
| 08/21 | 20 - 26 L | 0-2-0 | - | - | NFL Network | |
| 08/27 | 27 - 17 L | 0-3-0 | - | - | ||
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/12 Wk 1 | 41 - 33 L | 0-4-0 | - | - | FOX | |
| 09/20 Wk 2 | 17 - 35 L | 0-5-0 | - | - | ESPN | |
| 09/26 Wk 3 | 19 - 17 L | 0-6-0 | - | - | CBS | |
| 10/03 Wk 4 | 14 - 24 L | 0-7-0 | - | - | FOX | |
| 10/10 Wk 5 | 17 - 19 L | 0-8-0 | - | - | FOX | |
| 10/17 Wk 6 | 34 - 11 L | 0-9-0 | - | - | FOX | |
| 10/24 Wk 7 | 19 - 28 L | 0-10-0 | - | - | FOX | |
| 10/31 Wk 8 | 44 - 6 L | 0-11-0 | - | - | FOX | |
| - | - | - | - | - | - | - |
| 11/14 Wk 10 | 16 - 16 Tie | 0-11-1 | - | - | FOX | |
| 11/21 Wk 11 | 10 - 13 L | 0-12-1 | - | - | FOX | |
| 11/25 Wk 12 | 16 - 14 L | 0-13-1 | - | - | FOX | |
| 12/05 Wk 13 | 27 - 29 W | 1-13-1 | - | - | CBS | |
| 12/12 Wk 14 | 10 - 38 L | 1-14-1 | - | - | FOX | |
| 12/19 Wk 15 | 12 - 30 W | 2-14-1 | - | - | FOX | |
| 12/26 Wk 16 | 16 - 20 L | 2-15-1 | - | - | FOX | |
| 01/02 Wk 17 | 29 - 51 L | 2-16-1 | - | - | FOX | |
| 01/09 Wk 18 | 30 - 37 W | 3-16-1 | - | - | FOX | |