2021 Arizona Cardinals Schedule
| Pre Season |
|---|
| Opponent |
| DAL |
| KC |
| @ NO |
| Reg. Season |
| Opponent |
| @ TEN |
| MIN |
| @ JAC |
| @ LAR |
| SF |
| @ CLE |
| HOU |
| GB |
| @ SF |
| CAR |
| @ SEA |
| BYE WEEK |
| @ CHI |
| LAR |
| @ DET |
| IND |
| @ DAL |
| SEA |
| Post Season |
| Opponent |
| @ LAR |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/13 | 16 - 19 W | 1-0-0 | - | - | NFL Network | |
| 08/20 | 17 - 10 L | 1-1-0 | - | - | ESPN | |
| 08/28 | Cancelled | - | - | |||
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/12 Wk 1 | 38 - 13 W | 2-1-0 | - | - | CBS | |
| 09/19 Wk 2 | 33 - 34 W | 3-1-0 | - | - | FOX | |
| 09/26 Wk 3 | 31 - 19 W | 4-1-0 | - | - | FOX | |
| 10/03 Wk 4 | 37 - 20 W | 5-1-0 | - | - | FOX | |
| 10/10 Wk 5 | 10 - 17 W | 6-1-0 | - | - | FOX | |
| 10/17 Wk 6 | 37 - 14 W | 7-1-0 | - | - | FOX | |
| 10/24 Wk 7 | 5 - 31 W | 8-1-0 | - | - | CBS | |
| 10/28 Wk 8 | 24 - 21 L | 8-2-0 | - | - | Amazon Prime Video | |
| 11/07 Wk 9 | 31 - 17 W | 9-2-0 | - | - | FOX | |
| 11/14 Wk 10 | 34 - 10 L | 9-3-0 | - | - | FOX | |
| 11/21 Wk 11 | 23 - 13 W | 10-3-0 | - | - | FOX | |
| - | - | - | - | - | - | - |
| 12/05 Wk 13 | 33 - 22 W | 11-3-0 | - | - | FOX | |
| 12/13 Wk 14 | 30 - 23 L | 11-4-0 | - | - | ESPN | |
| 12/19 Wk 15 | 12 - 30 L | 11-5-0 | - | - | FOX | |
| 12/25 Wk 16 | 22 - 16 L | 11-6-0 | - | - | NFL Network | |
| 01/02 Wk 17 | 25 - 22 W | 12-6-0 | - | - | FOX | |
| 01/09 Wk 18 | 38 - 30 L | 12-7-0 | - | - | FOX | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 01/17 Wk 19 (Pre) | 11 - 34 L | 12-8-0 | - | - | ABC | |