Dupree finished his career as one of the best defensive players in recent program history. He came to Kentucky as a tight end but quickly moved to defensive end and thrived in a hybrid defensive end/outside linebacker role as a Wildcat. Dupree finished his Kentucky career ranked second in program history with 23.5 sacks and added 235 tackles with 38 tackles for loss. As a senior, Dupree totaled 74 tackles, 12.5 tackles for loss, 7.5 sacks, two fumbles forced, a blocked kick and an interception returned for a game-winning touchdown vs. South Carolina. He was drafted in the first round of the 2015 draft by the Pittsburgh Steelers.